Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
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منابع مشابه
Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer
OBJECTIVE Desmoplasia and hypovascularity are thought to impede drug delivery in pancreatic ductal adenocarcinoma (PDAC). However, stromal depletion approaches have failed to show clinical responses in patients. Here, we aimed to revisit the role of the tumour microenvironment as a physical barrier for gemcitabine delivery. DESIGN Gemcitabine metabolites were analysed in LSL-KrasG12D/+ ; LSL-...
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ژورنال
عنوان ژورنال: Gut
سال: 2017
ISSN: 0017-5749,1468-3288
DOI: 10.1136/gutjnl-2016-311954